Some info from Serebii:
1. The movie takes place in New Tork City (...) where Ash & co. have gone to learn about Pokemon Hills. (Isn't Castelia City suppose to be based on New York City? Though I will give the writers credit for remembering that at the end of Mewtwo Returns we saw him in a city that looks like New York City (though during the beginning of Jirachi: Wish Maker we also say him wearing a bad@$$ brown cape which he doesn't seem to have, unfortunately))
2. The Sableye we've seen in the trailer is from Pokemon Hills so it's not a new Pokemon for Ash & co.. (So I guess that means there's still a chance Sableye won't get an evolution in Gen VI
)
3. There's a statement saying we don't know the REAL Mewtwo yet. Apparently Mewtwo is having an existential problem where he thinks to himself about how the 5 Genesect shouldn't exist, just like he doesn't. (Didn't we already sort of cover this problem? I mean we never addressed it directly, but I thought at the end of Mewtwo Returns that Mewtwo came to the conclusion that even him and the other clone Pokemon have a place in this world which is why he went world hopping. Oh well, all I can say is that I better see Mewtwo use Psystrike at some point)